Farah’s disease was first reported in the 30s of the twentieth century. It is an inherited disease (cerebral vascular calcification). In most cases, the so-called group of pathologies in which the affected regions of the brain and blood vessels. Calcium salts are deposited in the walls of tiny arteries, capillaries. Farah syndrome occurs around the age of 40-50 years, but there are earlier cases in its manifestations.
A GROUP OF NEURODEGENERATIVE DISEASES
The central nervous system characterizes the group of diseases. A certain number of neurons die, which leads to neurological disorders. Neurodegenerative disorders can have several causes and different clinical indications. Significantly, all conditions in this category are incurable. All therapies, which were used, were symptomatic. It facilitates the presentation of the disease but does not contribute to the regeneration of damaged areas. The most effective would be neural tissue transplantation. However, this method has both technical and moral obstacles. For such diseases include Alzheimer’s disease, Parkinson’s, Farah. Usually, the diagnosis of the disease is in the early stages of utrudnena. Most often, the diagnosis of experts is based on patient complaints and observations of their behavior. But the primary tool is a scan (calculated, magnetic resonance).
SYMPTOMATOLOGY OF THE DISEASE
Because the disease – a rare phenomenon, experts find it difficult to feed him the correct clinical picture of the syndrome. Symptoms can occur if patients are older than 40 years. In younger people, Fara disease symptoms can be vague and vague. Patients have disturbed coordination of movements, parkinsonism. Also, the development of the disease may indicate symptoms such as chills, dystonia, rapid and irregular foot movements (Korie), and involuntary contractions of the hands and feet because the disease affects areas of the brain, the reduced working ability, mental ability. Also suffers and the human memory. They are often violated, and this. Other neurological signs may include pain, mental illness. Identify the juvenile form of the disease, which manifests itself in children, adolescents. The main symptoms, in this case, are the following: dystonia, Korie, seizures of epilepsy. The useless form is characteristic of middle and older ages. There is parkinsonism, speech disorders, other problems with the nervous system. It can also be urinary incontinence. Learn more about cool drawing idea.
POSSIBLE CAUSES OF FARAH SYNDROME
The reasons due to which the disease can develop are not well established. However, it is known that a significant impact on its occurrence is disorders of the thyroid, parathyroid glands. When failures occur in the exchange process, calcium, phosphorus, such neurodegenerative diseases, can occur with conditions of acid-base balance in the body. Alkalosis, leading to a significant loss of acid. But the alkaline compound is present in excess. There is also a view that the syndrome is manifested in Farah genetic disorders. That is a mutated gene responsible for replacing such elements as calcium. However, this version has many conflicts. Known isolated cases, when the symptoms of the disease manifested after irradiation of the head, poisoning toxins, lead, in children with Down syndrome. Also, calcification is diagnosed in humans, rubella (rare). Another possible cause of calcification of the basal ganglia – birth damage.
RESEARCH METHODS FOR EVALUATION
Before the onset of CT, patients underwent radiological studies of the brain. Thanks to modern research methods, experts have received more informative images from the affected areas. However, it should note that the increased sensitivity for a given clinical image has a computer rather than magnetic resonance imaging. In the analysis of most of the pictures, the affected area is limited to a pale orb. They are small in size. Most often suffer changes in the basal ganglia, thalamus, cerebellum. The level of calcification is around the same that those children have for adults. Differences also found between the groups, where the disease was asymptomatic Farah,
HISTOLOGICAL STUDIES
During the post-mortem examination, the brain situation is as follows: vessels have a whitish appearance (some branching sites). When touching the knife, they make a sound like a crunch. For histological examination of biopsy specimens, the section of the cerebral cortex, basal ganglia, the cerebellum was performed. It is in the last calcification occurs most often. Examples of calcium salts are present. Also, more often, they are identified in the arteries (small, medium), the capillaries. Less common (sporadic cases) Farah’s disease hits the vein. Throughout the vessel’s length and in the surrounding tissues, calcium conglomerates were seen in small sizes. Also, in isolated tissues having traces of arsenic,
RECOGNITION
Depending on whether the symptoms of Farah’s disease, the diagnosis may utrudnyatsya some. Often it is diagnosed by chance, spending imaging to confirm a completely different condition. First of all, experts do not violate calcium metabolism and other malformations. They were then assigned to computed tomography (or X-ray examination). Doctors note that one of the problems with the correct diagnosis sequence is hypoparathyroidism. The disease, which occurs when the lack of parathyroid hormone. As a result, blood calcium levels drop, and phosphorus levels increase. If the CT scan is observed calcification striopallidozubchatyh structures, and then to distinguish hypoparathyroidism from a condition such as Farah’s disease, further analyzes. First of all, it is essential to determine the level of parathyroid hormone and calcium. They are also used in the diagnosis of the parasitic defeat of the nervous system. Specific effects happen in the blood, cerebrospinal fluid. Rarely, headlamp pain is differentiated with such conditions as Bourneville sclerosis.
TREATMENT
Eliminating calcium concentrations, which are formed in the brain and blood vessels, is impossible. As a rule, the treatment of this disease is symptomatic. First of all, it aims at improving the metabolism of calcium and phosphorus in the body. If symptoms are observed in Parkinson’s disease, the specialist prescribes certain drugs (levodopa). Farah also disease, the treatment of its manifestations, involves using antioxidants, agents for improving metabolism. Treatment with calcium channel blockers is ineffective. It is worth it because the disease is rare and poorly understood. In most cases, therapy is to alleviate the symptomatic manifestations of the disease,
PROJECTION OF HEADLAMP PAIN
Because this condition violates the brain’s metabolism and calcium salts and irritates its tissue, the disease Farah Forecasts are somewhat ambiguous. The infection progresses moderately with age, calcium deposits development. Of course, all this will not happen in a year. In general, neurodegenerative diseases progress over several decades. The main problem is the lack of information on the state and the lack of specific treatment. Therefore, therapy is aimed at improving the quality of life of patients. Another negative point – bad pain is diagnosed in the early stages.
